"Dr. Pickle and Mrs. Pryde" is likely a slight misremembering of the title of the 1925 silent comedy horror film Dr. Pyckle and Mr. Pryde. This American black-and-white silent film was released on July 30, 1925, and stars Stan Laurel as the titular character. It is a two-reel spoof of the various Dr. Jekyll and Mr. Hyde films and adaptations of Robert Louis Stevenson's novella that were popular at the time. In the film, the esteemed Dr. Pyckle develops a new drug that, instead of turning him into a murderous villain, transforms him into "Mr. Pryde," a compulsive prankster who commits trivial acts of wrongdoing, such as stealing a child's ice cream cone.