An AFB-DNA (TB-PCR) Detection by Real-Time PCR with Reflex to Rifampicin Resistance by Ultra CBNAAT on Tissue is an advanced molecular test specifically designed to diagnose Histopathological or Extrapulmonary Tuberculosis (EPTB) within solid organ systems and structural tissues.

When tuberculosis manifests outside the lungs, it frequently forms deep-seated lesions or granulomas. Because the concentration of live bacteria in these dense tissues is often incredibly low (paucibacillary), traditional microscope smears and standard biopsy stains can easily miss them. This panel extracts the genetic blueprint (DNA) directly from tissue cells to deliver an incredibly rapid, ultra-sensitive diagnostic answer.

What Types of Tissue Specimens Are Evaluated?
This panel is performed on solid tissue biopsy specimens collected via needle aspiration, core biopsy, or surgical excision, including:

Lymph Nodes: Most commonly from cervical (neck), axillary, or mediastinal lymph nodes to diagnose TB Lymphadenitis.

Bone and Joint Tissue: Collected from suspected skeletal structures to identify bone TB or Pott’s Disease (spinal tuberculosis).

Gastrointestinal / Peritoneal Tissue: Biopsies taken from the bowel wall lining or omentum during an endoscopy or laparoscopy.

Pleural / Pericardial Tissue: Small structural samples taken from the protective sacs around the lungs or heart.

Skin / Soft Tissue: From non-healing chronic ulcers, nodules, or deep abscesses.