An Aldolase Diagnostic Test is a clinical blood test that measures the levels of aldolase, an essential enzyme responsible for breaking down sugars into cellular energy.

While aldolase is found throughout the body, it is most highly concentrated in skeletal muscle tissue and the liver. When these tissues experience injury, inflammation, or disease, aldolase leaks directly into the bloodstream.

Clinicians primarily use this test to detect, monitor, and differentiate skeletal muscle disorders, such as muscular dystrophy, dermatomyositis, or severe muscle trauma, from neurological conditions. It can also help evaluate underlying liver damage.