An **Anti-dsDNA (Anti-double-stranded DNA) antibody** test detects autoantibodies that mistakenly target the genetic material inside a person's own cells. This test is highly specific and serving as a hallmark diagnostic marker for **Systemic Lupus Erythematosus (SLE)**, a chronic autoimmune disease.

Because anti-dsDNA levels fluctuate in tandem with disease activity, doctors frequently use this blood test to monitor **lupus flares** and assess the risk of organ damage. Elevated levels are particularly correlated with **lupus nephritis**, a serious complication involving kidney inflammation, making the test vital for managing and tailoring ongoing treatment strategies.