A buccal cavity large biopsy measuring 3 to 6 cm is an extensive surgical procedure indicated for evaluating substantial, persistent, or highly suspicious lesions within the inner cheek lining. Because of the considerable dimensions of the affected tissue, clinicians typically perform an incisional approach, removing a representative portion alongside healthy margins to establish a precise histopathological diagnosis.
Administered under local or regional anesthesia, the intervention requires meticulous surgical technique and strategic suturing to manage the large defect while minimizing functional impairment like scar contraction. The excised specimen is sent for microscopic evaluation to detect conditions such as squamous cell carcinoma or precancerous dysplasias.