The CD10 test is a diagnostic laboratory evaluation used in hematopathology to identify the CD10 protein, also known as Common Acute Lymphoblastic Leukemia Antigen (CALLA). Expressed on pre-B lymphocytes and germinal center B-cells, CD10 serves as a key cell-surface marker.
Using flow cytometry or immunohistochemistry on blood, bone marrow, or lymph node samples, the test helps clinicians distinguish specific lymphomas and leukemias. It is particularly crucial for diagnosing Pre B-cell Acute Lymphoblastic Leukemia (ALL), Follicular Lymphoma, and Burkitt Lymphoma. Ultimately, detecting CD10 expression aids doctors in precise cancer subtyping, risk stratification, and selecting targeted treatment plans.