The CD5 test is a diagnostic evaluation used in pathology and hematology to detect the expression of the CD5 protein on immune cells. CD5 is a cell-surface marker naturally present on mature T-lymphocytes and a small subset of B-lymphocytes.
Performed via flow cytometry or immunohistochemistry on blood, bone marrow, or tissue biopsies, the test helps clinicians distinguish and classify specific blood cancers. Abnormal expression of CD5 on B-cells strongly points toward conditions like Chronic Lymphocytic Leukemia (CLL) and Mantle Cell Lymphoma. Ultimately, this test plays a vital role in accurate cancer staging, guiding targeted therapies, and monitoring treatment response.

The CD10 test is a diagnostic laboratory evaluation used in hematopathology to identify the CD10 protein, also known as Common Acute Lymphoblastic Leukemia Antigen (CALLA). Expressed on pre-B lymphocytes and germinal center B-cells, CD10 serves as a key cell-surface marker.
Using flow cytometry or immunohistochemistry on blood, bone marrow, or lymph node samples, the test helps clinicians distinguish specific lymphomas and leukemias. It is particularly crucial for diagnosing Pre B-cell Acute Lymphoblastic Leukemia (ALL), Follicular Lymphoma, and Burkitt Lymphoma. Ultimately, detecting CD10 expression aids doctors in precise cancer subtyping, risk stratification, and selecting targeted treatment plans.